Sometimes we want to password protect or lock our computers' USB Ports to restrict certain users to use the USB port for their purposes. This is very helpful to the people who have secret information in their system and want to hide it from the others.
So if you also want to disable and password protect your USB drive for certain or all USB drives then here is a software for you called My USB Only.It is a USB Password Protection software that not only adds security to your USB ports but also safeguards your system from unauthorized access.
Features
1 - Password protect USB ports.
2 - Create a Device Whitelist which allows access to certain USB Drives specified by you to access the system without any software (like your own drive).
3 - Block untrusted USB Drives.
4 - Run it invisibly and easily.
Whenever you insert any USB drive it will ask for the correct password, if entered wrong you'll not be able to use the drive.
http://www.myusbonly.com/dload/myusbonly_setup.exe

I don't see any reason why someone want to lock his USb ports to restrict other users for accessing it.With a good antivirus u can protect your pc from malwares that originate from usb drives.

this tool is used for home computer which is used by family
or it can be used to prevent someone who wanted to steal your data

This tools is good if you want to provide the PC as a Demo. For example, free internet access. The user can use the computer for their internet needs but they can't copy to from the PC. That means, the PC basically just a demo to show the user the speed of the service.